Erythema elevatum diutinum (EED) is a rare, chronic dermatosis that is characterized by red–violet to red–brown papules, plaques, and. Erythema elevatum diutinum (EED) is a chronic form of leukocytoclastic vasculitis consisting of violaceous, red-brown, or yellowish papules. Erythema elevatum diutinum. Authoritative facts about the skin from DermNet New Zealand.

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Eritema elevatum diutinum as a differential diagnosis of rheumatic diseases: case report.

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EED has been described in association with numerous hematological abnormalities, especially myelodysplasia, myeloproliferative alterations, elevatkm myeloma, 3,11 cryoglobulinemia 12 and immunoglobulin G IgG or immunoglobulin A IgA paraproteinemias. This results in fibrin deposition in and around small dermal vessels during the later stages of the disease.

Local surgical excision can be beneficial for localized fibrotic nodules of EED. Over the course of the disease process, the lesions can change in color as well as an increase in size and quantity. Recently, it has been added to the group of elevafum dermatoses that are associated with HIV. Arthralgias may develop in underlying joints, but extracutaneous involvement is extremely rare.


Erythema elevatum diutinum–a report of two unusual patients.

Eritema elevatum diutinum | Actas Dermo-Sifiliográficas

It is probably mediated by immune complexes. Nevertheless, immunoelectrophoresis screening for monoclonal gammopathies as a marker of EED has been recommended. Direct immunofluorescence may reveal changes consistent with vasculitis, such as fibrin deposits, intravascularly and perivascularly, complement, and immunoglobulins IgG, IgA, IgM.

In general, their overall condition is not compromised. Pathology consists of leukocytoclastic vasculitis in early stage lesions and a granulation-tissue-like response with fibrosis in later stages.

Pathology Outlines – Erythema elevatum diutinum

It often recurs after apparently successful treatment. View All Subscription Options. Views Read Edit View history. Report of three cases. Immune complex deposition results in complement activation, neutrophilic infiltration, and the release of destructive enzymes.

In other projects Wikimedia Commons. A skin biopsy is the most useful study for the diagnosis of EED. Diutinumm on Demand Journal. Jessica Newburger ; George J. The lesions are persistent and symmetrically distributed on extensor surfaces, particularly in the joints of the extremities. Erythema elevatum diutinum associated with IgA paraproteinemia successfully controlled with intermittent plasma exchange. The staining properties of the endothelium in EED were EED is a chronic and progressive skin disease that may last as long as 25 years.


Show details Treasure Island FL: History and Physical On exam, dlevatum of EED present as red—brown, yellowish, or violaceous papules, diutinu, or nodules.

Erythema elevatum diutinum

Today, one-and-a-half years after the HIV-positive blood test and the beginning of antiretroviral therapy, the patient has not had any recurrence of the skin lesions. Other therapies include NSAIDs, niacinamide, tetracyclines, chloroquine, colchicine, and plasmapheresis. Sulfone therapy in the treatment of leukocytoclastic vasculitis.

This page was last edited on 2 Mayat How to cite this article. Erythema elevatum diutinum EED is a chronic and rare dermatosis that is considered to be a variant of leukocytoclastic vasculitis. Typically, the lesions are asymptomatic, but there have been reports of patients who experienced pruritus and burning or tingling sensations, especially early in the disease course. Extracutaneous symptoms include arthralgia, fever, or other constitutional symptoms.

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